Neuro-Ophthalmology Lab

Sun Yat-sen University

State Key Laboratory of Ophthalmology

Research Interest

His research mainly focuses on pathological neovascularization in the ocular fundus and neurodegenerative disease of the retina, especially related to lysosomal dysfunction. He is also interested in exploring the underlying pathogenesis of optic neuritis as well as searching various targets, which are effective in clinical diagnosis and treatment.

Publication：

Gong Y, Qiu K, Zhou X.Ocular pathological changes in neurodegenerative diseases. Eye Science. 2023,38(3):225-238. DOI:10.12419/j.issn.1000-4432.2023.03.06. (in Chinese)

Lai K#, Gong Y#, Zhao W, Li L, Huang C, Xu F,Zhong X, Jin C..Triptolide attenuates laser-induced choroidal neovascularization via M2 macrophage in a mouse model. Biomed Pharmacother. 2020 Sep;129:110312. doi: 10.1016/j.biopha.2020.110312.

Lai K#, Gong Y#, Xu F, Li L, Huang C, Zhou L, Zhong X, Yang H, Lu L, Jin C .Effectiveness and Safety of Intravitreal Injection of Conbercept as an Initial Treatment for Exudative Circumscribed Choroidal Haemangioma[J]. Ophthalmologica. 2020;243(6):436-443. doi: 10.1159/000505753.

Lai K, Li Y, Gong Y, Li L, Huang C, Xu F, Zhong X, Jin C.. Triptolide-nanoliposome-APRPG, a novel sustained-release drug delivery system targeting vascular endothelial cells, enhances the inhibitory effects of triptolide on laser-induced choroidal neovascularization. Biomed Pharmacother. 2020 Nov;131:110737. doi: 10.1016/j.biopha.2020.110737.

Gong Y, Lai K, Li L. Nicotine aggravates experimental choroidal neovascularization by modulating macrophage polarization. Chinese Journal of Pathophysiology. 2020,36(1): 104-111. DOI: 10.3969/j.issn.1000-4718.2020.01.015.(in Chinese)

Gong Y, Lai K, Jin C.Research status of nicotine-aggravating the choroidal neovascularization formation in wet age-related macular degeneration. Chinese Journal of Ocular Fundus Diseases. 2020, 36(4): 319-322. doi: 10.3760/cma.j.cn511434-20180704-00226. (in Chinese)