Loss of Tmem106b leads to cerebellum Purkinje cell death and motor deficits

Rademakers R#, Nicholson AM, Ren Y, Koga S, Nguyen HP, Brooks M, Qiao W, Quicksall ZS, Matchett B, Perkerson RB, Kurti A, Castanedes-Casey M, Phillips V, Librero AL, Fernandez De Castro CH, Baker MC, Roemer SF, Murray ME, Asmann Y, Fryer JD, Bu G, Dickson DW, Zhou X#

Lysosomal Dysfunction and Other Pathomechanisms in FTLD: Evidence from Progranulin Genetics and Biology.

Zhou X, Kukar T, Rademakers R.

Loss of Tmem106b exacerbates FTD pathologies and causes motor deficits in progranulin deficient mice

Zhou X#, Brooks M, Jiang P, Koga S, Zuberi A, Baker M, Parsons T, Castanedes-Casey M, Phillips V, Librero A, Kurti A, Fryer J, Bu G, Lutz C, Dickson D#, and Rademakers R#

A role of the frontotemporal lobar degeneration risk factor TMEM106B in myelination

Feng T, Sheng RR, Solé-Domènech S, Ullah M, Zhou X, Mendoza CS, Enriquez LCM, Katz II, Paushter DH, Sullivan PM, Wu X, Maxfield FR, Hu F.

Loss of TMEM106B leads to myelination deficits: implications for frontotemporal dementia treatment strategies

Zhou X#, Nicholson AM, Ren Y, Brooks M, Jiang P, Zuberi A, Phuoc HN, Perkerson RB, Matchett B, Parsons TM, Finch NA, Lin W, Qiao W, Castanedes-Casey M, Phillips V, Librero AL, Asmann Y, Bu G, Murray ME, Lutz C, Dickson DW, Rademakers R#.

Progranulin deficiency leads to reduced glucocerebrosidase activity

Zhou X, Paushter DH, Pagan MD, Kim D, Nunez Santos M, Lieberman RL, Overkleeft HS, Sun Y, Smolka MB, Hu F.

Potential genetic modifiers of disease risk and age at onset in patients with frontotemporal lobar degeneration and GRN mutations: a genome-wide association study

Pottier C*, Zhou X*,Perkerson RB 3rd, Baker M, Jenkins GD, Serie DJ, Ghidoni R, Benussi L, Binetti G, López de Munain A, Zulaica M, Moreno F, Le Ber I, Pasquier F, Hannequin D, Sánchez-Valle R, Antonell A, Lladó A, Parsons TM, Finch NA, Finger EC, Lippa CF, Huey ED, Neumann M, Heutink P, Synofzik M, Wilke C, Rissman RA, Slawek J, Sitek E, Johannsen P, Nielsen JE, Ren Y, van Blitterswijk M, DeJesus-Hernandez M, Christopher E, Murray ME, Bieniek KF, Evers BM, Ferrari C, Rollinson S, Richardson A, Scarpini E, Fumagalli GG, Padovani A, Hardy J, Momeni P, Ferrari R, Frangipane F, Maletta R, Anfossi M, Gallo M, Petrucelli L, Suh E, Lopez OL, Wong TH, van Rooij JGJ, Seelaar H, Mead S, Caselli RJ, Reiman EM, Noel Sabbagh M, Kjolby M, Nykjaer A, Karydas AM, Boxer AL, Grinberg LT, Grafman J, Spina S, Oblak A, Mesulam MM, Weintraub S, Geula C, Hodges JR, Piguet O, Brooks WS, Irwin DJ, Trojanowski JQ, Lee EB, Josephs KA, Parisi JE, Ertekin-Taner N, Knopman DS, Nacmias B, Piaceri I, Bagnoli S, Sorbi S, Gearing M, Glass J, Beach TG, Black SE, Masellis M, Rogaeva E, Vonsattel JP, Honig LS, Kofler J, Bruni AC, Snowden J, Mann D, Pickering-Brown S, Diehl-Schmid J, Winkelmann J, Galimberti D, Graff C, Öijerstedt L, Troakes C, Al-Sarraj S, Cruchaga C, Cairns NJ, Rohrer JD, Halliday GM, Kwok JB, van Swieten JC, White CL 3rd, Ghetti B, Murell JR, Mackenzie IRA, Hsiung GR, Borroni B, Rossi G, Tagliavini F, Wszolek ZK, Petersen RC, Bigio EH, Grossman M, Van Deerlin VM, Seeley WW, Miller BL, Graff-Radford NR, Boeve BF, Dickson DW, Biernacka JM, Rademakers R.

The Interaction Between Progranulin with Sortilin and the Lysosome

Zhou X, Sullivan PM, Paushter DH, Hu F.

Partial Tmem106b reduction does not correct abnormalities due to progranulin haploinsufficiency

Arrant AE, Nicholson AM, Zhou X, Rademakers R, Roberson ED.

Loss of Tmem106b is unable to ameliorate frontotemporal dementia-like phenotypes in an AAV mouse model of C9ORF72-repeat induced toxicity

Nicholson AM*, Zhou X*, Perkerson RB, Parsons TM, Chew J, Brooks M, DeJesus-Hernandez M, Finch NA, Matchett BJ, Kurti A, Jansen-West KR, Perkerson E, Daughrity L, Castanedes-Casey M, Rousseau L, Phillips V, Hu F, Gendron TF, Murray ME, Dickson DW, Fryer JD, Petrucelli L, Rademakers R.

Lipopolysaccharide-Induced Microglia Activation Promotes the Survival of Midbrain Dopaminergic Neurons In Vitro

Zhou X, Spittau B.

TMEM106B and myelination: rare leukodystrophy families reveal unexpected connections

Zhou X, Rademakers R

The interaction between progranulin and prosaposin is mediated by granulins and the linker region between saposin B and C

Zhou X*, Sullivan PM*, Sun L, Hu F.

Lysosomal processing of progranulin

Zhou X*, Paushter DH*, Feng T, Sun L, Reinheckel T, Hu F.

Regulation of cathepsin D activity by the FTLD protein progranulin

Zhou X, Paushter DH, Feng T, Pardon CM, Mendoza CS, Hu F

Impaired prosaposin lysosomal trafficking in frontotemporal lobar degeneration due to progranulin mutations

Zhou X, Sun L, Bracko O, Choi JW, Jia Y, Nana AL, Brady OA, Hernandez JCC, Nishimura N, Seeley WW, Hu F

Interleukin-4 Protects Dopaminergic Neurons In vitro but Is Dispensable for MPTP-Induced Neurodegeneration In vivo

Hühner L, Rilka J, Gilsbach R, Zhou X, Machado V, Spittau B.

Elevated TMEM106B levels exaggerate lipofuscin accumulation and lysosomal dysfunction in aged mice with progranulin deficiency

Zhou X*, Sun L*, Brady OA, Murphy KA, Hu F.

The ALS/FTLD associated protein C9orf72 associates with SMCR8 and WDR41 to regulate the autophagy-lysosome pathway

Sullivan PM, Zhou X, Robins AM, Paushter DH, Kim D, Smolka MB, Hu F.

Expression of Tgfβ1 and Inflammatory Markers in the 6-hydroxydopamine Mouse Model of Parkinson's Disease

Haas SJ, Zhou X, Machado V, Wree A, Krieglstein K, Spittau B

Prosaposin facilitates sortilin-independent lysosomal trafficking of progranulin

Zhou X, Sun L, Bastos de Oliveira F, Qi X, Brown WJ, Smolka MB, Sun Y, Hu F.

TGFβ1 inhibits IFNγ-mediated microglia activation and protects mDA neurons from IFNγ-driven neurotoxicity

Zhou X, Zöller T, Krieglstein K, Spittau B.

Regulated intramembrane proteolysis of the frontotemporal lobar degeneration risk factor, TMEM106B, by signal peptide peptidase-like 2a (SPPL2a)

Brady OA, Zhou X, Hu F.

Establishment of a survival and toxic cellular model for Parkinson's disease from chicken mesencephalon

Tolosa A*, Zhou X*, Spittau B, Krieglstein K.

Endogenous transforming growth factor-beta promotes quiescence of primary microglia in vitro

Spittau B, Wullkopf L, Zhou X, Rilka J, Pfeifer D, Krieglstein K.

IL6 protects MN9D cells and midbrain dopaminergic neurons from MPP+-induced neurodegeneration

Spittau B, Zhou X, Ming M, Krieglstein K.

TGFβ signalling plays an important role in IL4-induced alternative activation of microglia.

Zhou X, Spittau B, Krieglstein K.

Macrophages acquire fibroblast characteristics in a rat model of proliferative vitreoretinopathy

Lin ML, Li YP, Li ZR, Lin JX, Zhou X, Liang D.

• Zhou X, Kukar T, and Rademakers R. Lysosomal dysfunction and other pathomechanisms in FTLD: Evidence from Progranulin genetics and biology. In: Frontotemporal Dementias 2020.
• Zhou X, Sullivan P, Paushter D, and Hu F. Methods to study interaction of progranulin with sortilin and the lysosome. In: Progranulin 2018.
• Sullivan P, Zhou X, Hu F. Autophagy-lysosome dysfunction in amyotrophic lateral sclerosis and frontotemporal lobar degeneration In: Lysosomes-associated diseases and methods to study its function. 2017.
• 周孝来、李永平 章节：“眼葡萄膜解剖”《眼科临床解剖学》刘祖国、颜建华主编 山东科学技术出版社2009年