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Clinical and Basical Research

Dr. Xiaolai Zhou is a Professor of Ophthalmology and a Principal Investigator of the Neuro-Ophthalmology Lab in the State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University (SYSU). Dr. Zhou received his M.D. from Hengyang Medical School, University of South China (2006) and Master's Degree in Ophthalmology from Zhongshan Ophthalmic Center, SYSU (2009). He obtained his Ph.D. in Neurobiology in Dr. Kerstin Krieglstein’s lab (2013) at the Department of Anatomy and Cell Biology in University of Freiburg, Germany, and conducted his postdoctoral training in Dr. Fenghua Hu’s lab at Weill Institute for Molecular & Cell Biology, Cornell University (2013-2017). Immediately after his postdoctoral training, Dr. Zhou joined Mayo Clinic (Jacksonville) as an Assistant Professor, where he worked closely with Dr. Rosa Rademakers, Dr. Dennis Dickson, and Dr. Guojun Bu. In December 2020, Dr. Zhou accepted the ‘Bairen’ professorship of Sun Yat-sen University, set up his research lab in the State Key Laboratory of Ophthalmology in Zhongshan Ophthalmic Center. Dr. Zhou worked on the molecular and genetic mechanisms of lysosomal dysfunction related-brain and -retinal degeneration. Specifically, his research focused on frontotemporal lobar degeneration and retinal degeneration caused by Progranulin (PGRN) gene mutation. Dr. Zhou’s research has been published in peer-review journals, such as Lancet Neurol., Nat Commun., Brain, Acta Neuropathol., J Cell Biology, EMBO Rep.